Talk:Gramine
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unsourced
[edit]moved here per PRESERVE
- Uses
Gramine is used mostly in synthetic organic chemistry as a starting material for tryptophan syntheses.
All reactions of gramine follow the same general reaction scheme. Gramine is reacted with a strong electrophile, such as methyl iodide, to form the quaternary ammonium salt 2. The ammonium salt will undergo a Hofmann elimination or Michael addition to give the very active intermediate 3, which can accept a wide range of nucleophiles to give the desired product 4.
It did say that gramine has use in the synthesis of Bucindolol as well as laboratory man-made Indole-3-carbinol oligomers.
-- Jytdog (talk) 02:47, 21 September 2017 (UTC)
Dubious reference claims
[edit]The 1st reference given is questionable as to whether it indicates that Gramine is 'toxic' to 'many organisms' as stated in the entry. More details or a specific quote needs to be given to accept the statement, and as to How toxic. Historianofentheogens (talk) 01:20, 29 March 2025 (UTC)